山东第二医科大学公共卫生学院欢迎访问山东第二医科大学公共卫生学院
山东第二医科大学公共卫生学院
当前位置:首页  师资队伍  博士研究生导师  劳动卫生与环境卫生学研究方向博士研究生导师
赵荣兰个人简介
发布者:ggxy    发表时间:2025-02-25

赵 荣 兰

一、个人简介

赵荣兰,博士,教授,现为临床生物化学教研室主任。潍坊市中西医结合学第二届检验专业委员会委员;山东生物化学与分子生物学会干细胞与精准医学专业委员会委员。参编教材2部,承担本科生和研究生5 门课程教学工作,智慧树线上课程和省级虚拟仿真实验教学一流课程负责人,主持校和厅级教改项目 4 , 第四位获第八届高等教育省级教学成果奖二等奖1项。主持国家自然科学基金2项、山东省自然科学基金3项(含重大基础专项 1 项),发表论文 50 多篇,20于篇被SCI收录。获山东省高等学校科学技术奖二等奖 1 项;申报国家发明专利 3 项,授权国家发明专利 2 项;获国家计算机软件著作权专利 1 项。目前3名在读研究生。邮箱:ronglanzhao@sdsmu.edu.cn.

二、研究方向

研究方向和研究领域的描述:分子内分泌与骨代谢、受体信号通路研究。

三、代表性科研项目

1ATP/P2X7受体信号通路对实验性自身免疫性葡萄膜 炎的时相性调节(81770915),国家自然科学基金项目,2018.01-2021.12, 第一位,56万元;

2、甲状腺激素受体beta亚型不保守的DBD与抗肿瘤作用(81301737),国家自然科学基金项目,2014.01-2016.12, 第一位,23万元;

3P2X7受体介导eATP驱动非小细胞肺癌生长和转移的分子机制及靶向治疗研究(ZR2023MH307),山东省自然科学基金项目,2024.01-2026.12,第一位,10万元;

4、高转染效率壳聚糖荷载IL-RaIGF-1基因治疗软骨损伤的实验研究(ZR2012HQ034),山东省自然科学基金项目,2012.01-2015.12,第一位,6万元;

5P2X7 受体参与肿瘤微环境中CD39/eATP轴调控实体瘤的功能及机制研究(ZR2021MH306),山东省自然科学基金项目,2022.01-2024.12,第二位,10万元;

四、代表性论文

1Xin Wang,Xiaoxiang Peng,Yahui Cao,Xiaodi Zhu,Yanan Du,Qingqing Yu,Ronglan Zhao(通讯作者). The Purinergic Ligand-Gated Ion Channel 7 Receptor Promotes the Proliferation, Invasion, and Migration of Breast Cancer Cells, Journal of biochemical and molecular toxicology, 2025, 39(2): e70184.

2Xin Wang, Qingqing Yu, Xue Bai, Xinyu Li, Yanli Sun, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). The role of the purinergic ligand-gated ion channel 7 receptor in common digestive system cancers, European journal of cancer prevention, 2024, 33(3):271-281.

3Xue Bai, Qianqian Li, Xiaoxiang Peng, Xinyu Li, Cuicui Qiao, Yiqing Tang, Ronglan Zhao(通讯作者). P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways, Purinergic Signalling, 2023, 19(4): 685-697.

4Xiaoxiang Peng, Yunfang Zhang, Xue Bai, Xinyu Li; Ronglan Zhao(通讯作者). Phasic regulation of the ATP/P2X7 receptor signaling pathway affects the function of antigen-presenting cells in experimental autoimmune uveitis, International immunopharmacology, 2023, 119: 110241.

5Xinyu Li, Xue Bai, Yiqing Tang, Cuicui Qiao, Ronglan Zhao(共通讯作者), Xiaoxiang Peng(共通讯作者). Research progress on the P2X7 receptor in liver injury and hepatocellular carcinoma. Chemical biology & drug design, 2023,101(3):794-808. 

6Xiaodi Zhu, Qianqian Li, Wei Song, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). P2X7 receptor: a critical regulator and potential target for breast cancer, Journal of molecular medicine, 2021, 99(3): 349-358.

7Mingxuan Li, Shuping Luo; Yunfang Zhang, Lina Jia; Chuanyu Yang, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). Production, characterization, and application of a monoclonal antibody specific for the extracellular domain of human P2X7R, Applied Microbiology and Biotechnology, 2020, 104(5): 2017- 2028.

8Mingxuan Li, Chuanyu Yang; Yunhai Wang, Wei Song, Lina Jia, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). The Expression of P2X7 Receptor on Th1, Th17, and Regulatory T Cells in Patients with Systemic Lupus Erythematosus or Rheumatoid Arthritis and Its Correlations with Active Disease, Journal of Immunology, 2020, 205(7): 1752-1762.

9Qianqian Li, Xiaodi Zhu, Wei Song, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). The P2X7 purinergic receptor: a potential therapeutic target for lung cancer, Journal of cancer research and clinical oncology,2020,146(11):2731-2741.

10Ronglan Zhao, Jinjuan Qiao, Xumei Zhang, Yansong Zhao, Xiangying Meng,Deming Sun, Xiaoxiang Peng (通讯作者). Toll-Like Receptor-Mediated Activation of CD39 Internalization in BMDCs Leads to Extra cellular ATP Accumulation and Facilitates P2X7 Receptor Activation, Frontiers in Immunology, 2019, 10: 2524.