赵 荣 兰
一、个人简介
赵荣兰,博士,教授,现为临床生物化学教研室主任。潍坊市中西医结合学第二届检验专业委员会委员;山东生物化学与分子生物学会干细胞与精准医学专业委员会委员。参编教材2部,承担本科生和研究生5 门课程教学工作,智慧树线上课程和省级虚拟仿真实验教学一流课程负责人,主持校和厅级教改项目 4 项, 第四位获第八届高等教育省级教学成果奖二等奖1项。主持国家自然科学基金2项、山东省自然科学基金3项(含重大基础专项 1 项),发表论文 50 多篇,20于篇被SCI收录。获山东省高等学校科学技术奖二等奖 1 项;申报国家发明专利 3 项,授权国家发明专利 2 项;获国家计算机软件著作权专利 1 项。目前3名在读研究生。邮箱:ronglanzhao@sdsmu.edu.cn.
二、研究方向
研究方向和研究领域的描述:分子内分泌与骨代谢、受体信号通路研究。
三、代表性科研项目(
1、ATP/P2X7受体信号通路对实验性自身免疫性葡萄膜 炎的时相性调节(81770915),国家自然科学基金项目,2018.01-2021.12, 第一位,56万元;
2、甲状腺激素受体beta亚型不保守的DBD与抗肿瘤作用(81301737),国家自然科学基金项目,2014.01-2016.12, 第一位,23万元;
3、P2X7受体介导eATP驱动非小细胞肺癌生长和转移的分子机制及靶向治疗研究(ZR2023MH307),山东省自然科学基金项目,2024.01-2026.12,第一位,10万元;
4、高转染效率壳聚糖荷载IL-Ra及IGF-1基因治疗软骨损伤的实验研究(ZR2012HQ034),山东省自然科学基金项目,2012.01-2015.12,第一位,6万元;
5、P2X7 受体参与肿瘤微环境中CD39/eATP轴调控实体瘤的功能及机制研究(ZR2021MH306),山东省自然科学基金项目,2022.01-2024.12,第二位,10万元;
四、代表性论文
1、Xin Wang,Xiaoxiang Peng,Yahui Cao,Xiaodi Zhu,Yanan Du,Qingqing Yu,Ronglan Zhao(通讯作者). The Purinergic Ligand-Gated Ion Channel 7 Receptor Promotes the Proliferation, Invasion, and Migration of Breast Cancer Cells, Journal of biochemical and molecular toxicology, 2025, 39(2): e70184.
2、Xin Wang, Qingqing Yu, Xue Bai, Xinyu Li, Yanli Sun, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). The role of the purinergic ligand-gated ion channel 7 receptor in common digestive system cancers, European journal of cancer prevention, 2024, 33(3):271-281.
3、Xue Bai, Qianqian Li, Xiaoxiang Peng, Xinyu Li, Cuicui Qiao, Yiqing Tang, Ronglan Zhao(通讯作者). P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways, Purinergic Signalling, 2023, 19(4): 685-697.
4、Xiaoxiang Peng, Yunfang Zhang, Xue Bai, Xinyu Li; Ronglan Zhao(通讯作者). Phasic regulation of the ATP/P2X7 receptor signaling pathway affects the function of antigen-presenting cells in experimental autoimmune uveitis, International immunopharmacology, 2023, 119: 110241.
5、Xinyu Li, Xue Bai, Yiqing Tang, Cuicui Qiao, Ronglan Zhao(共通讯作者), Xiaoxiang Peng(共通讯作者). Research progress on the P2X7 receptor in liver injury and hepatocellular carcinoma. Chemical biology & drug design, 2023,101(3):794-808.
6、Xiaodi Zhu, Qianqian Li, Wei Song, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). P2X7 receptor: a critical regulator and potential target for breast cancer, Journal of molecular medicine, 2021, 99(3): 349-358.
7、Mingxuan Li, Shuping Luo; Yunfang Zhang, Lina Jia; Chuanyu Yang, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). Production, characterization, and application of a monoclonal antibody specific for the extracellular domain of human P2X7R, Applied Microbiology and Biotechnology, 2020, 104(5): 2017- 2028.
8、Mingxuan Li, Chuanyu Yang; Yunhai Wang, Wei Song, Lina Jia, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). The Expression of P2X7 Receptor on Th1, Th17, and Regulatory T Cells in Patients with Systemic Lupus Erythematosus or Rheumatoid Arthritis and Its Correlations with Active Disease, Journal of Immunology, 2020, 205(7): 1752-1762.
9、Qianqian Li, Xiaodi Zhu, Wei Song, Xiaoxiang Peng(共通讯作者), Ronglan Zhao(共通讯作者). The P2X7 purinergic receptor: a potential therapeutic target for lung cancer, Journal of cancer research and clinical oncology,2020,146(11):2731-2741.
10、Ronglan Zhao, Jinjuan Qiao, Xumei Zhang, Yansong Zhao, Xiangying Meng,Deming Sun, Xiaoxiang Peng (通讯作者). Toll-Like Receptor-Mediated Activation of CD39 Internalization in BMDCs Leads to Extra cellular ATP Accumulation and Facilitates P2X7 Receptor Activation, Frontiers in Immunology, 2019, 10: 2524.